题 目👵🏼：Basic knowledge on nuclear receptors and their involvements in human pathologies
报告人：Jacques Samarut 教授
主持人👩🏽🔬：翁杰敏 教授
时 间： 2015年10月19日下午15:00-15:30 （周一下午）
地 点❇️：闵行校区天美娱乐534报告厅
报告人简介👰🏽：Jacques Samarut got his PhD at the University of Lyon in 1982. He was then appointed as Associate Professor at the Rockefeller University of New York and then as Invited Professor at the Institute of Medical Science, University of Tokyo. He is presently professor of molecular biology at the Faculty of Medicine, Université Claude Bernard, Lyon. From 2008 to 2014 he has been the President of the Ecole Normale Supérieure de Lyon a prestigious graduate school. He had been formerly director of the Life Sciences study section of the French National Agency for Scientific Research (CNRS) and President of the scientific advisory board of the French National Institute for Agronomy (INRA). He received several awards including the Leukemia award of the French League against Cancer (1987) and the Rosen Award Foundation for Medical Research, Paris (1990), and the silver medal of the CNRS (1997) for his work on the role of oncogenes and nuclear receptors in oncogenic transformation. He is presently working on genomics of nuclear receptors. He published more than 160 original articles in international scientific journals. His research work generated several patents and contributed to the creation of two biotech companies (Genoway, Vivalis). He was honored as Chevalier de la Légion d’Honneur and Officier de l’Ordre National du Mérite. He is Doctor Honoris Causa of the University of Ottawa and Honorary Professor and Higher End Expert of the East China University of Shanghai.
报告内容简介🧕🏿：In Vertebrates Thyroid hormone (TH) has many different functions during development but also throughout adult life. It works by binding to its nuclear receptors TR which are transcription factors regulated by the availability of their ligand TH. In mammals two genes THRA and THRB respectively encode the two receptors TRa and TRb. Our group has a long lasting interest in dissecting the respective biological functions of these two receptors in mouse. To this end we have generated a large library of mice harboring mutations in the genes encoding the receptors. The characterization of these mice allowed us to show that TRa and TRb mainly fulfill different functions even though they can compensate for each other in some specific cases, such as body temperature control. In the past we have studied in details TRa during development and in particular its central role for the maturation of many organs such as central nervous system, intestine, heart or bone. More recently we shifted thematic to focus on TR functions in the adult. We currently study how they are involved in the regulation of many aspects of lipid and glucose homeostasis in the principal metabolic organs: liver, white fat and pancreas. We recently showed that TRa knock out was associated to accelerated atherosclerosis in mice harboring and ApoE knock-out background. Molecular investigations of this phenomenon lead to identify the development of inflammation processes consecutive to the absence of TRa.
