讲座题目: Gripping Histone Marks for Transcriptional Control

主讲人: 李海涛，清华大学医天美研究员

主持人:翁杰敏 教授

开始时间:2014-12-2 13:30

讲座地址:闵行生科院534报告厅

主办单位:天美娱乐 科技处

 

报告人简介：李海涛博士，1997年获得山东大学微生物系微生物学学士，2003年获得中国科天美生物物理研究所分子生物物理学博士🤱🏿，2003年至2006年在美国纪念斯隆-凯特琳癌症中心任博士后研究员，2006年至2010年任美国纪念斯隆-凯特琳癌症中心高级研究科学家，2010年至今任清华大学医天美基础医学系和结构生物学中心研究员。

 

报告摘要：Dr. Li’s research is directed towards a molecular understanding of epigenetic regulations - the way our genetic information is organized and decoded at chromosomal level. Epigenetic mechanisms involve chemical modifications to histones or DNA, histone variants, chromatin remodeling, and non-coding RNAs. Growing evidence shows that epigenetic regulations play key roles in many biological processes, and it has become clear that their dysregulation can give rise to diverse diseases, notably cancer. The Li laboratory mainly applies macromolecular X-ray crystallography amongst other modern biophysical or biochemical techniques to study the structure and function of key epigenetic regulators, with an ultimate goal for epigenetic drug discovery. His major achievements in the past have been to elucidate the molecular basis for histone modification readout by a wealth of "reader" modules or their combinations. Examples include PHD finger (Nature, 2006), WD40 repeats (Nat Struc & Mol Biol, 2006), MBT (Mol Cell, 2007), PHD-Bromo (Cell, 2010, 2011), ADD (Nat Struc & Mol Biol, 2011), Spin/Ssty repeats (Genes Dev, 2014), Bromo-PWWP (Nature, 2014) and YEATS domain (Cell, 2014).